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D-ribose for brain energy in autism/ADHD

Digestion, Health, Nutrition                                   Facebook Dr. Anil

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 Antibiotics in meat: A case for organic food Does Influenza and Antibiotic Use During Pregnancy Increase  Autism
Ketogenic diet as treatment for autism Effect of Gut Bacteria on Ultimate Health Starts During Pregnancy
 Is Honey Better or Worse than Commonly Used Cough Medicines in Kids Autism and ADHD: Role of abnormal mitochondrial function
 Do Autism and ADHD Share Heredity? Old Stone Age Paleo Diet As Model For Autism Treatment
Zinc deficiency and autism: Is there a link?  How to pick a probiotic  for digestive disorders?

Digestion, Health, Nutrition                                   Facebook Dr. Anil

Ketogenic Diet and Autism

Ketogenic diet is reputed to be “neuroprotective” against brain dysfunction and is popular for use against epilepsy. At the same time, it is being touted for a variety of nervous system disorders like brain trauma, cognitive impairment,  Alzheimer’s and even cancer.

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Tricyclic antidepressants and autism

All fish are not same: Low v high mercury fish 

Quinoa: one complete high protein food

Health benefits of probiotics and prebiotics

Oral health in autism: dental caries and gums gingivitis

FODMAP diet: one type of elimination diet to try

Zinc supplements boost immune sytem and reduce respiratory infections

Turmeric: A must-have healthy spice in kitchen.

Use of elimination diet in autism

Food allergies and intolerance are not the same

Do cranberry and/or mannose protect against urinary tract infections or UTI

Coconut oil repairs unhealthy skin

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Blog: Digestion, Health and Nutrition

Autism: Celecoxib COX-2 nonsteroidal antiinflammatory agent improves symptoms

COX-2 inhibitor celecoxib

  1. COX-2 inhibitor effective against inflammatory conditions like arthritis
  2. COX-2 inhibitors rebalance type-1 and type-2 immune dysfunction
  3. COX-2 inhibitors prevent death of brain cells
  4. Beneficial effects of celecoxib  in early schizophrenia (Muller 2011)
  5. Beneficial effect of celecoxib as adjunct to risperidone in schizophrenia (Akhondzadeh 2007)
  6. Beneficial effect Aspirin as adjuvant to usual antipsychotic treatment of schizophrenia (Laan et al 2010)
  7. Beneficial effects in major depression

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 Guide to Alternative Medicine and the Digestive System

Swallowing problem EE and SFED Elimination Diet

Autism: It’s Gut stupid             Join Facebook group Autism: It’s Gut Stupid

What is Six-Food Elimination Diet or SFED?

SFED diet  involves exclusion of following from diet:

  • Cow’s milk
  • Soy
  • Eggs
  • Wheat
  • Peanuts
  • Tree nuts
  • Fish especially shell fish

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Autism treatment: Benefit of L-carnitine

All fish are not same: Low v high mercury fish

Quinoa: one complete high protein food

Health benefits of probiotics and prebiotics

Oral health in autism: dental caries and gums gingivitis

FODMAP diet: one type of elimination diet to try

Zinc supplements boost immune sytem and reduce respiratory infections

Turmeric: A must-have healthy spice in kitchen.

Use of elimination diet in autism

Food allergies and intolerance are not the same

Do cranberry and/or mannose protect against urinary tract infections or UTI

Coconut oil repairs unhealthy skin

Dental sickness affects rest of body

Autism rising prevalence and gut framework

Complimentary and Alternative Medicine for major depression

Probiotics de-stress gut dysfunction

Fasting, health and longevity

Yoga is not just exercise, has health benefits

Acupuncture for digestive and other disorders

Probiotics on market

Melatonin is not just for sleep, helps gut

Homeopathy: Fact or fiction

Eating orders and spirituality

Lifestyle measures to improve upper digestive health

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Cyproheptadine treatment of autism

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Mast cells are postulated to play a key role in immune system, allergies including eczema, autoimmune disorders like multiple sclerosis, rheumatoid arthritis etc. Clinical manifestations are varied including headache/migraine, abdominal migraine , skin allergies and eczema, respiratory allergies, and food allergies, asthma, urticaria, gastrointestinal disturbances, many of which appear to be more common in autism.

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 Guide to Alternative Medicine and the Digestive System

Micronutrients in autism superior to medications

Autism controversy: Do patients have more constipation

Leaky gut syndrome

Mangosteen: Is it good for health?

Autism: Role of leaky gut

Autism: Role of gut bacteria

Intestinal bacteria in health and disease

L-carnitine is of benefit in autism

Vitamin D and autism

Autism controversy: Role of Vitamin D

Migraine triggers and natural treatments

Celiac disease or gluten sensitive enteropathy

Do SSRI antidepressants help in repetitive behaviors of autism?

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Antidepressant medications particularly selective serotonin receptor inhibitors (SSRIs) are commonly used for treatment of behavioral problems including and not limited to the treatment of repetitive behaviors in autism spectrum disorders (ASD).

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Learn about 12-point autism treatment program   OR more topics of interest below

Autism treatment: Benefit of L-carnitine

All fish are not same: Low v high mercury fish  

Quinoa: one complete high protein food

Health benefits of probiotics and prebiotics

Oral health in autism: dental caries and gums gingivitis

FODMAP diet: one type of elimination diet to try

Zinc supplements boost immune sytem and reduce respiratory infections

Turmeric: A must-have healthy spice in kitchen.

Use of elimination diet in autism

Food allergies and intolerance are not the same

Do cranberry and/or mannose protect against  urinary tract infections or UTI 

Coconut oil repairs unhealthy skin

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Do Tricyclic Antidepressants Help in Autism

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While the use of tricyclic antidepressents in autism is common, how sure are we that they are actually effective, or it merely a placebo effect with side-effects? How do side-effects square with the strength of evidence for their efficacy in autism?

TCA-Autism Spectrum Disorders Study

Dr. Hurwitz and colleagues from the Department of Community Pediatrics, Liverpool Hospital, in Liverpool BC, NSW, Australia, conducted a meta-analysis and systemetic review of efficacy of TCAs in patients with autism.

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Omega6 Arachidonic acid and Autism

      By Anil Minocha MD, author: Guide to Alternative Medicine and the Digestive System

Polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and docosahexaenoic acid (DHA), an omega-3 fatty acid play a key role maturation of neural networks in brain. In fact DHA is critical for grey matter of brain and is associated with healthy cognitive and social functioning.

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Benefit of N-Acetylcysteine in Autism

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N-acetylcysteine and autism


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Probiotics: Do you know how to choose and use?

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  1. I suggest avoid taking probiotic with food so as not to subject the probiotic bacteria to peak digestive acid and juices
  2. Since the administered probiotic bacteria are transient inhabitants in the gut, I recommend taking probiotic twice a day in order to maintain a steady state and avoid sharp fluctuations.
  3. Data suggests that even killed probiotic bacteria may provide some health benefits

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Note: Probiotic supplementation is part of the 12-step treatment autism program.

Omega-3 Fatty Acids and Autism Spectrum Disorders

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Essential fatty acids and nervous system

  • Play a critical role in brain functions and transmission across nerves
  • Balance between various essential fatty acids is a major determinant in the maturation of brain function.
  • Inadequate 3-PUFA during the perinatal period in animal models leasd to disordered learning, neurotransmission and visual processes
  • Polyunsaturated fatty acids (PUFAs) can cross blood brain barrier and enter brain

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More treatment strategies at the 12-point treatment program for autism.

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Autism prevalence and gut-brain connection: Treating based on what we know

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Is the brain dysfunction of autism primary or secondary

What causes autism? Is the problem mainly in brain or the brain effects are secondary? Alterations in pace of growth of brain white matter may result in uncoordinated nerve cell-synapse communications.

Other factors implicated in autism  including age of parents, seizure disorders, problems with immune system and endocrine/hormonal system, dysfunction of the mitochondria that are responsible for respiration at cellular level.

Disordered gut provides unifying framework underlying autism

Invoking the gut at the core of the disorder may provide a unifying framework for better understanding of autism and its multiple diverse manifestations. The range of presentations may vary based on the qualitative and quantitative differences of the digestive factors involved.

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Other topics of interest:

Are micronutrients (vitamins and minerals) beneficial in autism?

Autism and constipation  controversy

Leaky gut syndrome

Is mangosteen good for health

Autism and leaky gut

Autism and gut bacteria  

Intestinal bacteria for health and disease

Gut bacteria genes and gut at interphase in autism 

L-carnitine treatment for autism

Vitamin D and autism

Migraine headache triggers  

Learn about celiac disease

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Fact or Fiction: Increased GI Problems in Autism

espite the overwhelming observations by families and scientific there remains a small section  of scientific community that has questioned such a difference based on minority  of literature (Kuddo T et al, Black C et al).
In fact, an editorial in the journal Pediatrics (Gilger et al) stated with confidence that  “putting to rest the nagging suggestion that there exists a link between autism  and gastrointestinal disease”.  However, many experts have argued against putting too much stock in this.

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Study: micronutrients (vitamins and minerals) superior to drugs for autism

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By Anil Minocha MD, author: Guide to Alternative Medicine and the Digestive System

Micronutrient deficiencies have been reported in patients with autistic spectrum disorders/ autism. Limited Literature  suggests that an improvement in a variety of behavioral problems occurs upon  micronutrient (vitamins and minerals) supplementation. At the same time, systematic review published in the prestigious journal Pediatrics points out that most routinely used medications do not meet criteria for evidence based medicine.

Potential mechanism of beneficial effect of micronutrients in autism:

  • Antioxidant activity
  • Improved mitochondrial function
  • Micronutrients  function as cofactors and as such have potential to improve metabolic efficiency at the level of neurotransmitters.

Autism-micronutrient vs drugs study background:  Dr. Mehl-Madrona and colleagues from the University of Hawaii School of Medicine, Honolulu, Hawaii. University of Calgary Faculty of Medicine, Calgary, Alberta, Canada. University of Manitoba, Winnipeg, Manitoba, sought to compare effect of micronutrient supplementation versus standard medical treatment for treatment of autism.

Autism-micronutrient study: Micronutrient group comprised of 44 subjects (2-28 years) that desired treatment without pharmaceutical medications. They were compared to 44 autistic kids whose parents requested medical treatment.

Results of autism and micronutrient versus medications  study:

Both treatments were effective in improving Childhood Autism Rating Scale and the Childhood Psychiatric Rating Scale.

Whether the behavioral improvements occurred via effect on mood dysfunction or directly their impact on autistic disorder is open to speculation.

Conclusions of the micronutrient vs medication autism study:

  • Treatment with micronutrients offers better results with lower activity level, improved social interaction, reduced SIB, anger and irritability.
  • Superior results on micronutrient therapy alone are accompanied by fewer side-effects and lesser weight gain.
  • Medical treatment offered advantages of insurance coverage, fewer pills, and less frequent
    dosing.
  • Medical treatment is not superior to micronutrient management for any of the clinical parameters measured.

Caveat: Just like most  of the literature on autism, this study not meet the evidence level of a  randomized controlled trial and is more reflective of evidence relying on
practice based medicine.

Note: Micronutrient (vitamins and minerals) supplementation is part of the 12-point treatment program for autism.

 Topics below may be of interest or go to Home page

Are micronutrients (vitamins and minerals) beneficial in autism?

Autism and constipation  controversy

Leaky gut syndrome  

Is mangosteen good for health 

Autism and leaky gut

Autism and gut bacteria  

Intestinal bacteria for health and disease

Gut bacteria genes and gut at interphase in autism  

L-carnitine treatment for autism 

Vitamin D and autism

Migraine headache triggers  

Learn about celiac disease

Home page       Join Facebook group Autism: It’s Gut Stupid    Facebook Dr. Anil 

Blog: Digestion, Health and Nutrition

Autism: It’s Gut Stupid

Home Page                   Facebook group Autism:It’sGut Stupid

By Anil Minocha MD, author: Guide to Alternative Medicine and the Digestive System

Welcome to Dr. Minocha’s new blog wherein he focus his attention mainly on peer-reviewed scientific studies and other info on gut and nutrition in the context of autistic spectrum disorders including autism. Such studies shall be cited appropriately.

While our knowledge about Autism/ASD continues to grow exponentially, much remains an enigma. Along the way, Dr. Minocha will offer his opinions as well. He is not the only clinician to do that. A recent peer-reviewed comprehensive systemetic review concluded that while numerous medical treatments are being prescribed by physicians, “strikingly little evidence” exists to support benefit for these treatments.

That may be due to the multifactorial nature of these disorders including a genetic predisposition. Further complicating the problem is the fact that there are multiple tpes/disorders clobbered into each of these conditions e.g. autism may not just have variants but are heterogeneous, in fact more than one distinct  disorder. When studies include subjects broadly, it can become difficult to replicate results of studies and hence this is one of one of the reasons for confusion on what causes these disorders and how can we heal them.

Multiple but not all studies have implicated gut and nutrition among the factors involved in the pathogenesis. The variability in results from different studies has led to the controvery surrounding the application of gut-nutrition hypothesis to these complex disorders. An analogy would be like various studies implicating gut/nutrition circling around the bulls-eye of autism/ASD. Whether these relationships are just a coincidence, an association or in fact represent causative mechanisms is open to debate.

Dr. Minocha believes that gut (for example hyperpermeability or leaky gut syndrome and dysbiosis or alterations in gut bacteria) along with nutrition play a sentinel role in causing and sustaining these disorders and hence should form one of the cores for treatment strategies e.g. 12 Point Autism Treatment Program With so much being unknown, other well-intentioned people may very well come to different conclusions.

Other topics of interest:

  1. Autism, leaky gut and elimination diets http://goo.gl/dRoFR
  2. Can probiotics strengthen selective intestinal barrier? http://goo.gl/cXmry
  3. Autism related to gut bacteria? http://goo.gl/omTSd
  4. Melatonin is not just for sleep. It helps gut too http://goo.gl/mKYOM
  5. Toileting posture: Taking care of business well! http://goo.gl/gCnsr

Review Autism Treatment Strategies at the 12-point treatment program for autism.

Topics below may be of interest or go to Home page

Are micronutrients (vitamins and minerals) beneficial in autism?

Autism and constipation  controversy

Leaky gut syndrome

Is mangosteen good for health

Autism and leaky gut

Autism and gut bacteria  

Intestinal bacteria for health and disease

Gut bacteria genes and gut at interphase in autism 

L-carnitine treatment for autism

Vitamin D and autism

Migraine headache triggers  

Learn about celiac disease

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Blog: Digestion, Health and Nutrition