Physical characteristics like mom’s poor nutrition and/or low birth weight, a marker of adverse intrauterine milieu and health is associated with increased risk of coronary heart disease, hypertension, type 2 diabetes, and osteoporosis in the child later on.
These chemicals transferred to fetus and its developing brain may include maternal antibodies as a result of infection, abnormal neurochemical signals due to altered brain-gut-bacteria communications in mother, absorbed bacterial toxic products with their antibodies as well as potentially noxious semi-digested food products.
Microbial transfer and contact of the mother with the growing baby in uterus as well as during delivery and breastfeeding cannot be ignored. In fact early exposures have affect the long term bacterial finger-print of the individual also termed as microbiological programming.
Enteric nervous system or second brain is more susceptible to mitochondrial dysfunction than brain
Nervous system of the gut also known as enteric nervous system is susceptible to mitochondrial dysfunction even more than the brain and is consistent with increased prevalence of gastrointestinal symptoms in patients with primary inherited mitochondrial disorders.