Mast cells are postulated to play a key role in immune system, allergies including eczema, autoimmune disorders like multiple sclerosis, rheumatoid arthritis etc. Clinical manifestations are varied including headache/migraine, abdominal migraine , skin allergies and eczema, respiratory allergies, and food allergies, asthma, urticaria, gastrointestinal disturbances, many of which appear to be more common in autism.
This involves transfer of entire bacterial flora from a healthy donor to the sick recipient. It has been used successfully to treat refractory as well as severe/recurrent cases of C. difficile colitis as well as inflammatory bowel disease (IBD).
• Protocols/recepies vary. I am not aware of any randomized controlled trials to examine most issues related to fecal transplantation.
NOTE: This article has been written in response to general requests for info, and NOT in any way to indicate this as a potential treatment for autism.
Multiple Western studies have demonstrated high levels of homocysteine in autism spectrum disorders. While autism is more common in th West, a similar correlation in Eastern societies also would lend support to hypothesis that folate-B12-homocyteine metabolism reactions may play a key role in environmental factors in autism.
Evidence suggests that there is increased prevalence of gastrointestinal symptoms (whether or organic or neurobehavioral) in autism. Based on gut-brain hypothesis, such symptoms could be the child’s method of communicating his/her symptoms to the care-giver.