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- Infection results not only just immune activation but also increased intestinal permeability or leaky gut along with alterations of intestinal bacteria or dysbiosis. Such intestinal changes can results in passage of potentially noxious substances/signals across the placenta to the developing fetus.
- These chemicals transferred to fetus and its developing brain may include maternal antibodies as a result of infection, abnormal neurochemical signals due to altered brain-gut-bacteria communications in mother, absorbed bacterial toxic products with their antibodies as well as potentially noxious semi-digested food products.
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