Lack of a specific laboratory abnormality and reliance on symptom complex makes diagnosis of autism unclear. Role of combined genetics and environment is suspected. Immune dysfunction is being increasingly recognized in pathogenesis. Gut is at the cross-roads on interplay between immune and nervous system. Intestinal bacteria as they move from neonatal bacterial flora to the adult bacterial pattern play a crucial role in the final make-up of the immune system which is interacting with the nervous system. Any disturbances along in later life can still upset the proverbial apple-cart making things worse.
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