Pathogenic mechanisms involved in autism include an imbalance of the oxidant stress, excitatory/inhibitory systems along with alterations in glutamatergic synapses and transmission of neuro-signals in the nervous system.
N-acetylcysteine (NAC) is an antioxidant and modulates glutamatergic excitatory neurogenic systems.
Constipation is occurs frequently in subjects with numerous chonic ailments including autism or autistic spectrum disorders and sometimes it’s just labelled as “functional”. Overall it is complex and an overall understanding including involvement of “big brain” (central nervous system), “our second brain” (enteric nervous system ) i.e. nervous system in gut) and brain-gut axis may explain why constipation is common among those suffering from autism/ASD.